CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
(2-chlorophenyl)(diphenyl)methanol
CAS: 66774-02-5
Molecular Formula: C19H15ClO
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL - Names and Identifiers
| Name | (2-chlorophenyl)(diphenyl)methanol |
| Synonyms | ClotriMazole IMpurity A o-chlorotriphenylmethanol Clotrimazole EP Impurity A ClotriMazole Related CoMpound A (2-chlorophenyl)(diphenyl)methanol Clotrimazole EP Impurity A(USP RC A) Benzenemethanol, 2-chloro-α,α-diphenyl- Clotrimazole Impurity 1(Clotrimazole EP Impurity A) |
| CAS | 66774-02-5 |
| InChI | InChI=1/C19H15ClO/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,21H |
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL - Physico-chemical Properties
| Molecular Formula | C19H15ClO |
| Molar Mass | 294.77 |
| Density | 1.216g/cm3 |
| Melting Point | 91-92 °C(Solv: acetic acid (64-19-7)) |
| Boling Point | 447.6°C at 760 mmHg |
| Flash Point | 224.5°C |
| Vapor Presure | 8.49E-09mmHg at 25°C |
| Appearance | Form Solid, color White to Pale Yellow |
| pKa | 12.36±0.29(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.627 |
| Physical and Chemical Properties | Chemical properties crystallization. Melting point 84-86 ℃. |
| Use | Intermediates of clotrimazole. |
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL - Risk and Safety
| HS Code | 2906290000 |
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL - Upstream Downstream Industry
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL - Production method
Use o-chlorobenzoic acid and ethanol to esterify with the participation of sulfuric acid or p-toluenesulfonic acid to generate ethyl o-chlorobenzoate, and then it is condensed with phenyl magnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl) diphenylmethanol magnesium salt, which is hydrolyzed with sulfuric acid to obtain the product.
Last Update：2024-04-10 22:29:15
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL - Nature
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
Last Update：2024-04-09 21:04:16
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View History
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
敌鼠钠
葡聚糖
3-烯丙基-4-(烯丙氧基)-5-甲氧基苯甲醛
2,4-DINITROBENZENESULFONIC ACID DIHYDRATE
敌鼠钠
葡聚糖
3-烯丙基-4-(烯丙氧基)-5-甲氧基苯甲醛
2,4-DINITROBENZENESULFONIC ACID DIHYDRATE
Raw Materials for CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
Downstream Products for CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL